The Key Problem: Delayed bleeding post-ESD is a critical clinical pain point.
Endoscopic submucosal dissection (ESD) is a cornerstone minimally invasive technique for treating superficial gastrointestinal tumors. While offering advantages like minimal trauma and rapid recovery, it is complicated by delayed bleeding (DB), which presents a significant clinical challenge. With an incidence rate ranging from 1.8% to 15.6%, DB is influenced by factors such as patient age, lesion size and location, and the use of antithrombotic agents. When it occurs, DB often necessitates emergency hospitalization, potentially requiring blood transfusion or repeat endoscopic intervention, thereby increasing patient morbidity and healthcare resource utilization. Consequently, the exploration of safe and highly effective post-procedural hemostatic strategies has become an urgent priority in the field of gastrointestinal endoscopy.
Academic research: Multi-center data validates the value of hemostatic powder
To evaluate the efficacy of hemostatic powder in preventing delayed bleeding after ESD, a multicenter retrospective study in the United States enrolled 83 patients (excluding those undergoing mucosal defect closure) who received the hemostatic powder after ESD at three clinical centers between January 2023 and March 2024. The patients had a median age of 66 years, and their lesions were located in the esophagus, stomach, colon, and rectum.
Results showed that after using hemostatic powder, only 3 patients (3.6%) experienced delayed bleeding after surgery, all of which occurred within 24 hours and stopped spontaneously, without the need for secondary endoscopic intervention. This suggests that effective hemostatic products must be easy to use, provide stable coverage, and be safe and reliable to meet the hemostatic needs of complex wounds after ESD surgery.
Product Spotlight: Xunning Meets the Core Needs of ESD Treatment
As a delicate endoscopic procedure, ESD treatment places extremely high demands on postoperative care in the three core areas of precise hemostasis, wound protection, and healing promotion. Xunning® Hemostatic Powder precisely meets these core requirements. As the first hemostatic powder to utilize dual plant-based ingredients, Xunning® Absorbable Complex Polysaccharide Hemostatic Powder offers the following advantages: 1. Safety: Its dual plant-based ingredients, cross-linked potato starch and sodium carboxymethyl starch, are non-antigenic and non-immunogenic. Metabolic testing at the Chinese Academy of Military Medical Sciences confirms that it is degraded within 2 days, absorbed within 7 days, and completely excreted within 30 days.